Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract
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- 作者：Tomokazu Ohnuma ; Eri Anzai ; Yohei Suzuki ; Mai Shimoda ; Shin Saito ; Takahito Nishiyama ; Kenichiro Ogura ; Akira Hiratsuka ; hiratuka@toyaku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf2 ; Cinnamomi Cortex ; Cancer cells ; Antiproliferation ; Procyanidin ; Suppression
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：585
- 期：Complete
- 页码：17-24
- 全文大小：1570 K
文摘
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We use procyanidins from Cinnamomi Cortex extract (CCE) as an Nrf2 inhibitor.
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Western blot analysis reveals constitutive activation of Nrf2 in cancer cells.
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CCE procyanidins suppress nuclear Nrf2 selectively in cancer cells with active Nrf2.
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Proliferation in cancer cells with activated Nrf2 is inhibited by CCE procyanidins.
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Transfection assay shows selective inhibition of activated Nrf2 by CCE procyanidins.