A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome
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- 作者：Nozomi Takahashia ; Miyuki Haradaa ; haradam-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yasushi Hirotaa ; Lin Zhaob ; Osamu Yoshinoc ; Yoko Urataa ; Gentaro Izumia ; Masashi Takamuraa ; Tetsuya Hirataa ; Kaori Kogaa ; Osamu Wada-Hiraikea ; Tomoyuki Fujiia ; Yutaka Osugaa
- 关键词：Endoplasmic reticulum stress ; Unfolded protein response ; Vascular endothelial growth factor A ; Ovarian hyperstimulation syndrome ; Ovary
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：428
- 期：Complete
- 页码：161-169
- 全文大小：610 K
文摘
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Cumulus cells from patients who developed OHSS are under greater ER stress.
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ER stress upregulates hCG-induced VEGFA production in granulosa lutein cells.
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An ER stress inhibitor prevents OHSS by reducing ovarian VEGFA production.
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ER stress represents a novel therapeutic target for prevention of OHSS.