Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes

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• 作者：Hideto Tamura ; Kazuo Dan ; Norio Yokose ; Rika Iwakiri ; Masatsugu Ohta ; Hisashi Sakamaki ; Kaoru Tohyama ; Asaka Kondo ; Hideya Hyodo ; Kyoko Nakamura ; Taishi Yamashita ; Olga A. Elisseeva ; Yoshihiro Oka ; Yu
• 关键词：WT1 ; MDS ; Prognosis
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：34
• 期：8
• 页码：986-990
• 全文大小：330 K

文摘

Wilms tumor gene (WT1) mRNA expression in peripheral blood cells was examined in 80 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) transformed from MDS. Serum anti-WT1 antibody titers were also determined in 45 patients. Their long-term follow-up showed that the survival rate became worse as the WT1 mRNA level increased. In particular, a high WT1 mRNA level was a strong predictor of a short time to AML transformation even if adjusted by the International Prognostic Scoring System category. Moreover, high values of anti-WT1 antibody were an independent predictor of longer survival. These data may justify therapeutic strategies targeting WT1 molecules in MDS.