LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage

详细信息    查看全文

• 作者：Lydia K. Lee¹ ; ² ; Yasamine Ghorbanian³ ; Wenyuan Wang¹ ; Yanling Wang¹ ; Yeon Joo Kim¹ ; Irving L. Weissman⁴ ; Matthew A. Inlay³ ; Hanna K.A. Mikkola¹ ; ⁵ ; ⁶ ; ^{hmikkola@mcdb.ucla.edu}
• 关键词：LYVE1 ; lineage tracing ; hemogenic endothelium ; yolk sac ; definitive hematopoiesis ; primitive hematopoiesis ; fetal liver
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2286-2298
• 全文大小：5444 K
• 卷排序：17

文摘

LYVE1 is expressed in yolk sac endothelium and hematopoietic stem and progenitor cells Lyve1-Cre marks yolk sac definitive hematopoiesis but bypasses primitive erythropoiesis LYVE1 lineage cells initiate fetal liver definitive erythropoiesis A subset of fetal and adult hematopoietic stem cells are derived from the LYVE1 lineage