• 作者：Xiao-Feng Li^a ; ¹ ; Hao-Long Dong^a ; ¹ ; Xing-Yao Huang^a ; ¹ ; Ye-Feng Qiu^b ; ¹ ; Hong-Jiang Wang^a ; ² ; Yong-Qiang Deng^a ; Na-Na Zhang^a ; ^c ; Qing Ye^a ; Hui Zhao^a ; Zhong-Yu Liu^a ; Hang Fan^a ; Xiao-Ping An^a ; Shi-Hui Sun^a ; Bo Gao^a ; Yun-Zhi Fa^b ; Yi-Gang Tong^a ; Fu-Chun Zhang^d ; George F. Gao^e ; Wu-Chun Cao^a ; Pei-Yong Shi^f ; Cheng-Feng Qin^a ; ^c ; ^{qincf@bmi.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Zika virus ; Non-human primate model ; Target organ ; Lacrimal fluid
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：170-177
• 全文大小：1569 K

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Subcutaneous inoculation of ZIKV causes fever and viremia in NHPs

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Robust viral RNA excretion was seen in urine, saliva, and lacrimal fluid.

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The intestinal tracts, spleen, parotid glands, and lymph nodes us are potential target organs.

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ZIKV infection induces robust humoral and cellular immune response.

Zika virus (ZIKV) is spreading throughout the world whereas no vaccine or drug is currently available. To better understand the disease, we established the non-human primate model with a ZIKV strain isolated in 2016. We found that ZIKV infection in Rhesus monkeys resulted in fever, and viral RNA were present in various body fluids, including blood, urine, saliva, and lacrimal fluids. We identified the intestinal tracts, spleen, parotid glands, and lymph nodes as potential target organs of ZIKV by necropsy. The animal model not only helps understand the disease, but also provides a powerful tool for vaccine and antiviral tests.