CT scanning-based phenotypes vary with ADRB2

详细信息    查看全文

• 作者：Woo Jin Kim ; Yeon-Mok Oh ; Joohon Sung ; Young Kyung Lee ; Joon Beom Seo ; NamKug Kim ; Tae-Hyung Kim ; Jin Won Huh ; Ji-Hyun Lee ; Eun-Kyung Kim ; Jin Hwa Lee ; Sang-Min Lee ; Sangyeub Lee ; Seong Yong Lim ; Tae Rim Shin ; Ho Il Yoon ; Sung-Youn Kwon ; Sang Do Lee
• 关键词：COPD ; Polymorphism ; Computed tomography
• 刊名：Respiratory Medicine
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：103
• 期：1
• 页码：98-103
• 全文大小：145 K

文摘

Summary

Background

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is characterized by varying degrees of involvement of airway and lung parenchyma. Although cigarette smoke is the major risk factor for COPD, the principal determining factors of involvement of the airway or lung parenchyma have not been clearly defined. Genetic variability in COPD patients might influence the varying degrees of involvement of airway and parenchyma. We therefore studied whether airway and parenchyma involvement might be associated with the ADRB2 genotype, which has been reported to be associated with COPD susceptibility and the bronchodilator response.

Methods

One hundred and eleven COPD subjects, whose post-bronchodilator FEV₁/FVC values were less than 0.7, and who had histories of smoking exceeding 10 pack-years, were prospectively recruited from pulmonology clinics of 11 hospitals in Seoul, Korea. The degrees of involvement of airway and parenchyma were evaluated by volumetric computed tomography (CT) scans. In-house software automatically calculated luminal areas, airway wall areas, percentages of wall areas in segmental bronchi, emphysema indices, and mean lung densities in the whole lung parenchyma. The ADRB2 genotypes at codon 16 were determined for all patients.

Results

Gly16 was associated with lumen diameter, luminal area, and percentage of wall area in patients with COPD (p = 0.02), whereas neither wall area nor wall thickness differed with ADRB2 genotype. Neither emphysema index nor mean lung density was associated with ADRB2 genotype.

Conclusion

Gly16 variant in ADRB2 gene was associated with airway wall phenotypes measured using CT scanning in COPD patients.