A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly
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- 作者：Neil Hattersley1 ; Dhanya Cheerambathur1 ; Mark Moyle1 ; Marine Stefanutti2 ; Amelia Richardson1 ; Kian-Yong Lee1 ; Julien Dumont2 ; Karen Oegema1 ; Arshad Desai1 ; 3 ; abdesai@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：nuclear pore ; ELYS ; MEL-28 ; kinetochore ; centromere ; meiosis ; chromosome segregation ; protein phosphatase 1 ; PP1 docking ; nuclear pore assembly
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：12 September 2016
- 年：2016
- 卷：38
- 期：5
- 页码：463-477
- 全文大小：4665 K
文摘
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The Y-complex nucleoporin MEL-28/ELYS is essential for meiosis I anaphase
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MEL-28 acts in meiosis I anaphase by docking protein phosphatase I (PP1c)
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MEL-28-PP1c promotes kinetochore disassembly-dependent segregation
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MEL-28-PP1c directs nuclear assembly and expansion during M-phase exit