Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE
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- 作者：Jacob J. Ormea ; Yong Dua ; c ; Kamala Vanarsaa ; c ; Jessica Mayeuxa ; Li Lia ; Azza Mutwallya ; Cristina Arriensa ; Soyoun Mina ; Jack Hutchesona ; Laurie S. Davisa ; Benjamin F. Chongb ; Anne B. Satterthwaitea ; Tianfu Wua ; c ; Chandra Mohana ; c ; cmohan@Central.UH.EDU" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANA ; Anti-nuclear antibodies ; Axl ; Axl tyrosine kinase (UFO) ; BMDM ; Bone marrow-derived macrophages ; GBM ; Glomerular basement membrane disease ; SLE ; Systemic lupus erythematosus ; PBMC ; Peripheral blood mononuclear cell
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：169
- 期：Complete
- 页码：58-68
- 全文大小：1427 K
文摘
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Axl receptor tyrosine kinase is cleaved and inactivated on SLE PBMCs.
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ADAM10 and TACE (ADAM17) are responsible for the cleavage of Axl in SLE.
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Axl-deficient macrophages drive systemic inflammation in a mouse model of nephritis.