Improvement of gene delivery of PDMAEMA by incorporating a hyperbranched polymer core

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• 作者：Haixing Cheng ; Hui Deng ; Linzhu Zhou ; Yue Su ; Songrui Yu ; Xinyuan Zhu ; Yongfeng Zhou ^{yfzhou@sjtu.edu.cn} ; Deyue Yan
• 关键词：Hyperbranched ; Gene transfection ; Cytotoxicity ; PDMAEMA
• 刊名：Journal of Controlled Release
• 出版年：2011
• 出版时间：30 November, 2011
• 年：2011
• 卷：152
• 期：supp_S1
• 页码：e187-e188
• 全文大小：1K

文摘

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Summary

A novel strategy to improve the transfection efficiency as well as lower the cytotoxicity for PDMAEMA polycationic vectors has been developed. The cytotoxicity decreases and the transfection efficiency increases significantly through the incorporation of a hydrophobic hyperbranched PEHO core into PDMAEMA. The effectiveness of the hyperbranched architecture for the gene transfection was further proved by comparing the PEHO-star-PDMAEMAs vector with a linear, molecular weight-analogous PEHO core as the control.