G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK
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- 作者：Hua Yanga ; 1 ; Haipeng Liua ; 1 ; Hao Chenb ; Haiping Mob ; Jianxia Chena ; Xiaocheng Huanga ; Ruijuan Zhenga ; Zhonghua Liua ; Yonghong Fenga ; Feng Liua ; Baoxue Gea ; b ; baoxue_ge@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mtb ; Mycobacterium tuberculosis ; GPCRs ; G protein-coupled receptors ; GFP ; green fluorescent protein ; PB ; PiggyBac ; OADC ; oleic acidalbumin-dextrose-catalase ; LVS ; Live Vaccine Strain ; MFI ; mean fluorescence intensity
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1145-1151
- 全文大小：965 K
文摘
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GPR160 is essential for BCG entry into macrophage.
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GPR160 regulates BCG entry into macrophages by modulating the activation of ERK signaling.
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gpr160−/− mice are more resistant to BCG infection.
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GPR160 may participate in uptake or phagocytosis of a series of bacteria.