Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway
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- 作者：Yuanzhou He ; Xiaopei Cao ; Xiansheng Liu ; doctorliu69@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiaochen Li ; Yongjian Xu ; Jin Liu ; Jing Shi
- 关键词：PAH ; pulmonary arterial hypertension ; PASMCs ; pulmonary arterial smooth muscle cells ; TrkA ; tyrosine kinase A ; NGF ; nerve growth factor ; RVSP ; right ventricular systolic pressure
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：339
- 期：1
- 页码：122-134
- 全文大小：14702 K
文摘
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Quercetin ameliorate hypoxia-induced PAH and pulmonary arterial remodeling.
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Quercetin reverses hypoxia-induced apoptosis resistance, cell cycle arrested and migration in PASMCs.
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Quercetin alleviate experimental PAH partially by modulating the TrkA/AKT signaling pathway.