Studies on the total synthesis of tenuifoliside B

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• 作者：Yongjiang Wu ; Qiyuan Shi ^{shiqiyuan@zju.edu.cn" class="auth_mail} ; Houliang Lei ; Xuesong Liu ; Lianjun Luan ; ^{lljun@zju.edu.cn" class="auth_mail}
• 关键词：Tenuifoliside B ; Polygala tenuifolia Willd ; Total synthesis ; Regiospecific esterification
• 刊名：Tetrahedron
• 出版年：17 June 2014
• 年：2014
• 卷：70
• 期：24
• 页码：3757-3761
• 全文大小：654 K

文摘

An efficient synthesis of tenuifoliside B, which shows potential cognitive improvement and cerebral protective effects that may be further developed to become an anti-AD lead compound, has been developed starting from commercial available starting materials. Regioselective introductions of acyl groups to the OH-3′ and OH-6 of sucrose play the key steps by metal chelate-directed acylation and Mitsunobu esterification, respectively.