Hydrogen sulfide promotes osteogenic differentiation of human periodontal ligament cells via p38-MAPK signaling pathway under proper tension stimulation
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- 作者：Zhaoxia Jiang ; Yongmei Hua ; yongmeihua@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author ; hebyjzx@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrogen sulfide ; Human periodontal ligament cells ; Cyclic tension ; Osteogenic differentiation ; p38-MAPK ; ERK
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：8-13
- 全文大小：1131 K
文摘
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Hydrogen sulfide (H2S) could promote osteogenic differentiation of human periodontal ligament cells.
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P38-MAPK signaling were activated in different ways upon induction by H2S.
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Expression of the osteogenic regulators was reversed by p38-MAPK and ERK signaling inhibitors SB203580 and U0126.