Copper-catalyzed cross-coupling of 1-haloalkyl-o-carboranes with Grignard reagents: an efficient route to monosubstituted o-carborane derivatives

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• 作者：Ju-You Lu ; Yongmei Du ; Bo Zhao ; Jian Lu ; ^{lujian204@263.net" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Copper-catalyzed ; Cross-coupling ; Carborane ; Grignard reagent ; Synthetic method
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：7 January 2016
• 年：2016
• 卷：72
• 期：1
• 页码：161-169
• 全文大小：1623 K

文摘

A convenient and efficient copper-catalyzed reaction has been developed for the synthesis of functionalized o-carborane derivatives by using a Cu/phosphine catalytic system. Cross-coupling of readily available 1-haloalkyl-o-carboranes with Grignard reagents proceeds efficiently under mild conditions, and the corresponding monosubstituted o-carboranes were obtained in good to excellent yields.