Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation
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- 作者：Weixin Zhanga ; Lianhong Yina ; Xufeng Taoa ; Lina Xua ; Lingli Zhengb ; zheng_ll2009@126.com" class="auth_mail" title="E-mail the corresponding author ; Xu Hana ; Youwei Xua ; Changyuan Wanga ; Jinyong Penga ; jinyongpeng2008@126.com" class="auth_mail" title="E-mail the corresponding author ; jinyongpeng2014@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sirt1 ; Sirtuin 1 ; DMN ; dimethylnitrosamine ; HO-1 ; Heme oxygenase -1 ; GST ; glutathione-S-transferase ; GCLC ; glutathione cysteine ligase catalytic subunit ; GCLM ; glutathione cysteine ligase modifier subunit ; Nrf2 ; NF-E2-related factor 2 ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; IRF9 ; interferon regulatory factor 9 ; Bak ; BCL2-antagonist/killer 1 ; Bcl-2 ; B-cell CLL/lymphoma 2 ; Caspase-3 ; cysteinylaspartate specific proteinase-3 ; Caspase-9 ; cysteinylaspartate specific proteinas
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：45
- 期：Complete
- 页码：193-201
- 全文大小：4236 K
文摘
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Dioscin showed potent effect against DMN-induced acute liver injury.
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Dioscin regulated TLR4/MyD88 signal pathway to suppress inflammation.
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Dioscin regulated Sirt1/Nrf2 signal pathway to suppress oxidative stress.
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Dioscin regulated IRF9 level to inhibit apoptosis.