Ti-55531 alloy with BM presents an excellent HCF strength (∼656 MPa). Slip lines, twins and dislocation free zones exist in fatigued specimens. Fatigue microcracks mainly nucleate at αp/βtrans interfaces and at αp phase. Fatigue cracks growth with a smooth path results from fine αs lamellae in βtrans. HCF damage of the alloy is controlled by both αp particles and αs platelets.