Maternal exposure effect of OTA on hippocampal neurogenesis was examined.
Type-2 progenitor granule cells in the SGZ were reversibly reduced upon weaning.
Reduced cholinergic signals and increased oxidative stress may affect neurogenesis.
BDNF increment might be a neuroprotective mechanism for disrupted neurogenesis.
The NOAEL for offspring neurogenesis was determined to be 39.3–76.0 μg/kg BW/day.