Intake of Japanese and Chinese teas reduces risk of Parkinson’s disease

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• 作者：Keiko Tanaka^a ; ^{k-tanaka@fukuoka-u.ac.jp"" rel=""nofollow} ; Yoshihiro Miyake^a ; Wakaba Fukushima^b ; Satoshi Sasaki^c ; Chikako Kiyohara^d ; Yoshio Tsuboi^e ; Tatsuo Yamada^e ; Tomoko Oeda^f ; Takami Miki^g ; Nobutoshi Kawamura^h ; Nobutaka Sakae^h ; Hidenao Fukuyamaⁱ ; Yoshio Hirota^b ; Masaki Nagai^j ; the Fukuoka Kinki Parkinson's Disease Study Group¹
• 关键词：Caffeine ; Case– ; control studies ; Coffee ; Japan ; Parkinson’ ; s disease
• 刊名：Parkinsonism and Related Disorders
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：17
• 期：6
• 页码：446-450
• 全文大小：143 K

文摘

Studies that have addressed the association between the intake of coffee or caffeine and Parkinson’s disease (PD) were conducted mainly in Western countries. Little is known about this relationship in an Asian population. Therefore, we performed an assessment of the association of the intake of coffee, other caffeine-containing beverages, and caffeine with the risk of PD in Japan. The study involved 249 PD cases and 368 control subjects. Information on dietary factors was obtained through a self-administered diet history questionnaire. Adjustment was made for sex, age, region of residence, educational level, pack-years of smoking, body mass index, the dietary glycemic index, and intake of cholesterol, vitamin E, β-carotene, vitamin B_6, alcohol, and iron. Intake of coffee, black tea, and Japanese and Chinese teas was significantly inversely associated with the risk of PD: the adjusted odds ratios in comparison of the highest with the lowest quartile were 0.52, 0.58, and 0.59, respectively (95 % confidence intervals = 0.30–0.90, 0.35–0.97, and 0.35–0.995, respectively). A clear inverse dose–response relationship between total caffeine intake and PD risk was observed. We confirmed that the intake of coffee and caffeine reduced the risk of PD. Furthermore, this is the first study to show a significant inverse relationship between the intake of Japanese and Chinese teas and the risk of PD.