Production of 5-aminolevulinic acid by Propionibacterium acidipropionici TISTR442

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• 作者：Pornpimon  ; Kiatpapan¹ ;   ; ^{pornpimon@rsu.ac.th} ; Manthana  ; Phonghatsabun¹ ; Mitsuo  ; Yamashita² ;   ; ^§ ; ; Yoshikatsu  ; Murooka² ;   ; ^§ ; § ; ; Watanalai  ; Panbangred³ ;   ; ⁴
• 关键词：Propionibacterium acidipropionici ; 5-Aminolevulinic acid ; Glycine ; ALA synthase ; ALA dehydratase
• 刊名：Journal of Bioscience and Bioengineering
• 出版年：2011
• 出版时间：April 2011
• 年：2011
• 卷：111
• 期：4
• 页码：425-428
• 全文大小：365 K

文摘

Propionibacterium acidipropionici TISTR442 produced the highest amount of 5-aminolevulinic acid (ALA) when cultivated in medium supplemented with glycine at 18 g/l. ALA production correlated with ALA synthase activity, whereas ALA dehydratase activity was maintained at a low level. ALA yield reached 405 mg/l after prolonged cultivation for 1 month.