- 作者：Takeshi Hanagiri ; MD ; PhD ; hanagiri@med.uoeh-u.ac.jp ; Yoshiki Shigematsu ; MD ; PhD ; Koji Kuroda ; MD ; PhD ; Tetsuro Baba ; MD ; PhD ; Hironobu Shiota ; MD ; PhD ; Yoshinobu Ichiki ; MD ; PhD ; Yoshika Nagata ; MD ; PhD ; Manabu Yasuda ; MD ; PhD ; Hidetaka Uramoto ; MD ; PhD ; Tomoko So ; MD ; PhD ; Mitsuhiro Takenoyama ; MD ; PhD ; Fumihiro Tanaka ; MD ; PhD
- 关键词：Non&ndash ; small-cell lung cancer ; HLA class I expression ; Surgery ; Prognosis ; Immunohistochemical staining ; Immune escape
- 刊名：Journal of Surgical Research
- 出版年：2013
- 出版时间：15 May, 2013
- 年：2013
- 卷：181
- 期：2
- 页码：e57-e63
- 全文大小：441 K
Background
The purpose of the present study was to clarify the prognostic significance of human leukocyte antigen (HLA) class I expression in patients with non-small-cell lung cancer who underwent complete surgical resection.Patients and methods
The expression of HLA class I molecules was evaluated in 403 resected NSCLC specimens using immunohistochemistry. The results were scored as the percentage of stained tumor cells and were categorized into three groups: 0 % -24 % (decreased), 25 % -79 % (heterogeneous), and 80 % or more (normal).
Results
The expression of HLA class I was evaluated in 124 tumors in the normal expression group, 181 tumors in the heterogeneous expression group, and 98 tumors in the decreased expression group. The 5-year survival rate of all patients after surgery according to the HLA class I expression in the normal, heterogeneous, and decreased groups was 76.6 % , 65.9 % , and 76.1 % , respectively. The prognosis was significantly better in the normal expression group than in the heterogeneous group. Normal HLA class I expression also correlated with favorable survival in patients with stage I disease.
Conclusions
The normal expression of HLA class I was associated with a favorable prognosis compared with the heterogeneous expression group, but no significant difference was observed between the normal expression and decreased expression groups.