Frequency and hemostatic abnormalities in pre-DIC patients

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• 作者：Kohji Okamoto ; Hideo Wada ; Tsuyoshi Hatada ; Toshimasa Uchiyama ; Kazuo Kawasugi ; Toshihiko Mayumi ; Satoshi G ; o ; Shigeki Kushimoto ; Yoshinobu Seki ; Seiji Madoiwa ; Hidesaku Asakura ; Shin Koga ; Toshiaki I
• 关键词：DIC ; Pre-DIC ; Hemostatic markers ; Mortality ; Resolution rate
• 刊名：Thrombosis Research
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：126
• 期：1
• 页码：74-78
• 全文大小：169 K

文摘

Disseminated intravascular coagulation (DIC) sometimes has a poor outcome, and therefore early diagnosis and treatment are required. This study prospectively evaluated the hemostatic abnormalities and the onset of DIC in 613 patients with underlying diseases to identify a useful marker for diagnosing Pre-DIC. Pre-DIC was defined as the condition of patients within a week before the onset of DIC.

Initially, 34.4 % of patients were diagnosed with DIC, and about 8.5 % of the patients without DIC were diagnosed as DIC within a week after registration (pre-DIC). The mortality of DIC, Pre-DIC and “without DIC” was 35.3 % , 32.4 % and 17.2 % , respectively. All hemostatic parameters were significantly worse in “DIC” than “without DIC” and the values of the prothrombin time ratio, platelet count and fibrin monomer complex could classify the three groups; “DIC”, “pre-DIC” and “without DIC”. No useful marker was identified that provided an adequate cutoff value to differentiate “pre-DIC” from “without DIC”. A multivariate analysis identified clinical symptoms that were related to poor outcome.

DIC must be treated immediately; there is no specific marker to identify pre-DIC.