Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates
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- 作者：Akinori Yamasaki1 ; 6 ; Yasunori Watanabe1 ; 6 ; 7 ; Wakana Adachi2 ; Kuninori Suzuki3 ; Kazuaki Matoba1 ; Hiromi Kirisako4 ; Hiroyuki Kumeta2 ; Hitoshi Nakatogawa4 ; Yoshinori Ohsumi5 ; Fuyuhiko Inagaki1 ; 2 ; Nobuo N. Noda1 ; nn@bikaken.or.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：19-27
- 全文大小：3584 K
文摘
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Crystal structure of prApe1 shows vertical projection of propeptides
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Self-assembled and Atg19-bound propeptides have a similar trimeric architecture
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Atg19 regulates the size of the Ape1 complex to be optimal for the Cvt pathway
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Atg19-blanketing of the Ape1 complex enables highly selective autophagy