A simple sarcopenia screening test predicts future adverse events in patients with heart failure

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• 作者：Yoshiro Onoue ; Yasuhiro Izumiya ; ^{izumiya@kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shinsuke Hanatani ; Tomoko Tanaka ; Satoru Yamamura ; Yuichi Kimura ; Satoshi Araki ; Kenji Sakamoto ; Kenichi Tsujita ; Eiichiro Yamamoto ; Megumi Yamamuro ; Sunao Kojima ; Koichi Kaikita ; Seiji Hokimoto
• 关键词：Sarcopenia ; Heart failure ; Risk stratification
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 July 2016
• 年：2016
• 卷：215
• 期：Complete
• 页码：301-306
• 全文大小：449 K

文摘

Progressive loss of skeletal muscle termed “sarcopenia” is an independent risk factor for mortality in patients with cardiovascular diseases. A simple screening test that can identify sarcopenia using three variables (age, grip strength and calf circumference) was recently developed. We evaluated the clinical utility of this screening test in patients with heart failure (HF).

Methods and results

HF patients were divided into the sarcopenia (n = 82) and non-sarcopenia (n = 37) groups based on the sarcopenia score. Circulating BNP and high-sensitive cardiac troponin T levels were significantly higher, and left ventricular ejection fraction was lower in the sarcopenia group than non-sarcopenia group. Kaplan–Meier curve showed that HF event-free survival rate was significantly lower in the sarcopenia group. Multivariate Cox proportional hazards analysis identified BNP (ln[BNP]) (hazard ratio [HR]: 1.58; 95% CI: 1.09–2.29, p = 0.02), hs-CRP (ln[CRP]) (HR: 1.82; 95% CI: 1.23–2.68; p < 0.01) and sarcopenia score (HR: 1.03; 95% CI: 1.01–1.05, p < 0.01) as independent predictors of HF events. In receiver operating characteristic analysis, adding the sarcopenia score to BNP levels increased an area under the curve for future HF events (sarcopenia score alone, 0.77; BNP alone, 0.82; combination, 0.89).

Conclusions

The sarcopenia screening test can be used to predict future adverse events in patients with HF.