Antibodies against peptides of NMDA-type GluR in cerebrospinal fluid of patients with epileptic spasms
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- 作者：Tatsuo Mori ; mori.tatsuo@tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yukitoshi Takahashi ; Nami Araya ; Taikan Oboshi ; Hirokazu Watanabe ; Kazuki Tsukamoto ; Tokito Yamaguchi ; Shinsaku Yoshitomi ; Hirosato Nasu ; Hiroko Ikeda ; Hideyuki Otani ; Katsumi Imai ; Hideo Shigematsu ; Yushi Inoue
- 关键词：West syndrome ; Infantile spasms ; Autoantibodies ; Cognitive outcome ; Motor outcome
- 刊名：European Journal of Paediatric Neurology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：20
- 期：6
- 页码：865-873
- 全文大小：1611 K
文摘
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The role of antibodies to NMDA-type GluR in CSF was investigated in ES patients.
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Significant difference of the antibodies between ES and disease controls was shown.
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Predictive value of antibodies for outcome was not confirmed.
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GluN2B antibodies were higher especially in ES patients with unknown cause.
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We suggested possible contribution of GluN2B antibodies to motor and cognitive outcomes.