Increased peripheral blood interferon gamma-producing T cells in acute disseminated encephalomyelitis
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- 作者：Yoshitomi ; Tomomi ; Matsubara ; Tomoyo ; Nishikawa ; Miki ; Katayama ; Kumiko ; Ichiyama ; Takashi ; et. al.
- 关键词：Acute disseminated encephalomyelitis ; Peripheral blood ; IFN-γ ; -producing T cells
- 刊名：Journal of Neuroimmunology
- 出版年：2000
- 出版时间：November 1, 2000
- 年：2000
- 卷：111
- 期：1-2
- 页码：224-228
- 全文大小：127 K
文摘
There have been few reports on immunological studies in patients with acute disseminated encephalomyelitis (ADEM). We investigated the immunological features of ADEM using flow cytometry to examine interferon gamma (IFN-γ)-and interleukin 4 (IL-4)-producing peripheral blood CD3+T cells from four patients with ADEM, three other neurological disorders (Fisher syndrome, epilepsy and aseptic meningitis) and 10 healthy children. IFN-γ-producing CD3+T cells were increased in ADEM during the acute stage. In a relapsing case of ADEM, the percentages of IFN-γ-producing CD3+T cells correlated with disease activity. There were no significant changes of IL-4-producing CD3+T cells in ADEM during the acute and convalescent stages. In conclusion, peripheral blood IFN-γ-producing T cells are related to the pathogenesis at the early phase of the acute ADEM.