Anti-cytokine autoantibodies are ubiquitous in healthy individuals
详细信息 查看全文
- 作者：Masato Watanabe ; Kanji Uchida ; Kazuhide Nakagaki ; Hiroko Kanazawa ; Bruce C. Trapnell ; Yoshihiko Hoshino ; Hiroshi Kagamu ; Hirohisa Yoshizawa ; Naoto Keicho ; Hajime Goto ; et al.
- 关键词：Autoantibody ; Cytokine ; Vascular endothelial growth factor ; Immune complex ; Healthy individual
- 刊名：FEBS Letters
- 出版年：2007
- 出版时间：15 May 2007
- 年：2007
- 卷：581
- 期：10
- 页码：2017-2021
- 全文大小：452 K
文摘
Anti-cytokine autoantibodies in healthy individuals have been widely reported but the occurrence is variable and inconstant. We hypothesized that cytokine-binding in vivo may explain their variable and infrequent detection. Therefore, we focused on the detection of the cytokine-autoantibody complexes and found that anti-cytokine autoantibody to IL-2, IL-8, tumor necrosis factor-α, vascular endothelial growth factor and granulocyte-colony stimulating factor were present in all 15 individuals evaluated, while those to IL-3, osteopontin and macrophage-colony stimulating factor were not detected in anyone. Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals.