Methods for differential and quantitative analyses of brain neurosteroid levels by LC/MS/MS with ESI-enhancing and isotope-coded derivatization
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- 作者：Tatsuya Higashi ; higashi@rs.tus.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Naoto Aiba ; Tomoya Tanaka ; Kazumi Yoshizawa ; Shoujiro Ogawa
- 关键词：Neurosteroid ; Rat brain ; LC/ESI&ndash ; MS/MS ; Isotope-coded derivatization ; Antipsychotic drug
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：155-162
- 全文大小：1109 K
文摘
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LC/ESI–MS/MS methods were developed for the analysis of brain neurosteroids (NSs).
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The methods were employed the isotope-coded derivatization technique.
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The methods enabled the differential and quantitative analyses of the brain NS levels.
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Changes in the levels by stress and antipsychotic drug administration were measured.