Cardiac arrest from acute myocardial infarction complicated with sodium-glucose cotransporter 2 inhibitor-associated ketoacidosis

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• 作者：Zhehao Dai ; MD^a ; Yosuke Nishihata ; MD ; PhD^b ; ^{hatasuke@luke.ac.jp} ; Naoto Kawamatsu ; MD^b ; Ikki Komatsu ; MD^b ; Atsushi Mizuno ; MD^b ; Masato Shimizu ; MD^c ; Nozomi Toya ; MD^c ; Shinichi Ishimatsu ; MD ; PhD^c ; Nobuyuki Komiyama ; MD ; PhD ; FJCC^b
• 关键词：Euglycemic diabetic ketoacidosis ; Sodium-glucose cotransporter 2 inhibitor ; Cardiac arrest ; Myocardial infarction ; Ventricular fibrillation
• 刊名：Journal of Cardiology Cases
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：2
• 页码：56-60
• 全文大小：1583 K
• 卷排序：15

文摘

Euglycemic diabetic ketoacidosis (DKA) has been recognized as a potentially fatal complication related to sodium-glucose cotransporter 2 (SGLT2) inhibitors. Herein, we report a patient of out-of-hospital cardiac arrest, with an initial cardiac rhythm of ventricular fibrillation, who was subsequently diagnosed with acute myocardial infarction, complicated with SGLT2 inhibitor-associated euglycemic DKA. The patient survived and achieved nearly full functional recovery. This report calls for increased attention to SGLT2 inhibitors’ fatal complications, as well as their proper use.<Learning objective: Euglycemic diabetic ketoacidosis could develop in patients using sodium-glucose cotransporter 2 inhibitors. It is a potentially lethal complication and needs more attention. Physicians who prescribe this class of drugs should be aware of this complication. Meanwhile, research to elucidate patient characteristics that are more susceptible to this complication is urgently awaited.>