New clerodane diterpenoids from Croton crassifolius

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• 作者：Maosong Qiu^b ; Di Cao^b ; Youheng Gao^b ; Shuhua Li^b ; Jinping Zhu^b ; Bao Yang^b ; Lian Zhou^b ; Yuan Zhou^b ; Jing Jin^a ; ^{jinjing@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhongxiang Zhao^b ; ^{zzx37@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Croton crassifolius ; Clerodane diterpenoids ; Alkaloid ; MTT method
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：108
• 期：Complete
• 页码：81-86
• 全文大小：576 K

文摘

Two new clerodane diterpenoids (1–2), one new clerodane diterpenoid alkaloid (3), as well as thirteen known compounds were isolated from Croton crassifolius. The structures of new compounds were established by a combination of spectroscopic methods, including HRMS, ¹H NMR, ¹³C NMR, ¹H ¹H COSY, HSQC, HMBC, NOESY and X-ray crystallographic analysis. Compound 3 is firstly reported as the clerodane-type diterpenoid alkaloid in natural products. All of the compounds were evaluated for in vitro cytotoxic activities against CT26.WT cell using the MTT method.