APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis
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- 作者：Youming Dinga ; Deling Zhangb ; Bin Wanga ; Yemin Zhangb ; Lei Wanga ; Xiaoyan Chena ; Mingxin Lib ; Zhao Tangb ; Changhua Wangb ; chwang0525@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：APPL1 ; Adiponectin ; STAT3 ; SirT1 ; Gluconeogenesis
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：433
- 期：Complete
- 页码：12-19
- 全文大小：1528 K
文摘
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APPL1 mediates anti-gluconeogenic properties of adiponectin.
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APPL1 positively regulates adiponectin-stimulated STAT3 activity.
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Adiponectin enhances association of APPL1 with SirT1.
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APPL1 modulates adiponectin-reduced interaction between SirT1 and STAT3.