Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis
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- 作者：Pengfei Li ; Youming Guo ; Grant Bledsoe ; Zhirong Yang ; Lee Chao ; Julie Chao ; chaoj@musc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kallistatin ; MicroRNAs ; Breast cancer ; Wnt signaling ; Apoptosis ; Autophagy
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：340
- 期：2
- 页码：305-314
- 全文大小：3582 K
文摘
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Kallistatin reduces viability and increases apoptosis in breast cancer cells.
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Kallistatin induces autophagy via suppressing Wnt signaling.
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Kallistatin via its active site regulates miR-21, miR-203 and miR-34a synthesis.
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Kallistatin inhibits miR-203 and increases SOCS3 levels via PKC-ERK signaling.
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Novel mechanisms of kallistatin in cancer cell death and tumor development.