Potential of l-thyroxine to differentiate osteoblast-like cells via Angiopoietin1
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- 作者：See-Hyoung Parka ; 1 ; Jongsung Leeb ; 1 ; Mi-Ae Kangc ; 1 ; Young Jae Moond ; Sung Il Wangc ; Kyoung Min Kime ; Byung-Hyun Parkd ; Kyu Yun Jange ; kyjang@chonbuk.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jung Ryul Kimc ; jrkeem@jbnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：l-Thyroxine ; Differentiation ; Osteoblast ; Angiopoietin1
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1409-1415
- 全文大小：1298 K
文摘
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A ELISA screening method for novel drug activating endogenous Ang1 is proposed.
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Ang1 expression was examined in U2OS with FDA-approved drugs.
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l-Thyroxine was selected as a novel drug candidate.
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l-Thyroxine could be a potential bone production agent.