Piperlongumine attenuates experimental autoimmune encephalomyelitis through inhibition of NF-kappaB activity

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• 作者：Sun Mi Gu^a ; ¹ ; Jaesuk Yun^b ; ¹ ; Dong Ju Son^a ; Hoi Yeong Kim^c ; Kyung Tak Nam^a ; Hae Deun Kim^a ; Min Gi Choi^a ; Jeong Soon Choi^a ; Young Min Kim^a ; Sang-Bae Han^a ; Jin Tae Hong^a ; ^{jinthong@chungbuk.ac.kr}
• 关键词：Multiple sclerosis ; Piperlongumine ; Experimental autoimmune encephalomyelitis ; Nuclear factor kappaB ; Neuroinflammation
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：133-145
• 全文大小：2584 K
• 卷排序：103

文摘

Piperlongumine improves EAE symptoms in C57BL/6 mice spinal cord. Piperlongumine inhibits NF-κB activity in RAW 264.7 and Jurkat cells. Piperlongumine could be useful for the treatment for multiple sclerosis.