Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
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- 作者：Megan M. Young1 ; 2 ; Yoshinori Takahashi2 ; Todd E. Fox3 ; Jong K. Yun1 ; Mark Kester3 ; Hong-Gang Wang1 ; 2 ; 4 ; hwang3@hmc.psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：sphingosine kinase 1 ; sphingosine ; sphingosine-1-phosphate ; endocytic trafficking ; late endosome ; autophagy
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1532-1545
- 全文大小：7319 K
文摘
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Inhibition of Sphk1 impairs endocytic trafficking to enlarge late endosomes
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Sphk1 aids in endosomal membrane fusion independent of catalytic activity
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Autophagy is induced, but flux is impaired by inhibition of Sphk1 with SK1-I
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Restored autophagic flux and lysosome biogenesis restore endosomal trafficking