Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes

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• 作者：Youngpyo Nam¹ ; Jae-Hong Kim¹ ; Jong-Heon Kim¹ ; Mithilesh Kumar Jha¹ ; Ji Young Jung¹ ; Maan-Gee Lee¹ ; In-Sun Choi² ; Il-Sung Jang² ; Dong Gun Lim³ ; Sung-Hun Hwang⁴ ; Hee-Jung Cho⁴ ; Kyoungho Suk¹ ; ⁵ ; ^{ksuk@knu.ac.kr}
• 关键词：pain ; astrocytes ; neuroinflammation ; optogenetics ; spinal cord ; central sensitization
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：3049-3061
• 全文大小：5927 K
• 卷排序：17

文摘

Optogenetics applied to spinal astrocytes in live animals Optogenetic stimulation of spinal astrocytes induces pain hypersensitivity Spinal astrocytic activation necessary/sufficient for optogenetic pain induction Suggests possible basis for therapeutic strategy for chronic pain