- 作者：Young Jin Ko ; Hee-Won Moon ; Mina Hur ; Yeo-Min Yun
- 关键词：ESBL ; Colonization ; Risk ; Factors
- 刊名：American Journal of Infection Control
- 出版年：December, 2013
- 年：2013
- 卷：41
- 期：12
- 页码：1241-1243
- 全文大小：165 K
Background
Colonization of multidrug-resistant microorganisms is a potential source of cross transmission and subsequent infection. Screening of extended-spectrum 尾-lactamase-producing Enterobacteriaceae (ESBL-E) is not yet a routine practice in most hospitals.Methods
The purpose of this study was to investigate the risk factors of fecal carriage of ESBL-E in hospitalized patients. A total of 174 samples (from 97 patients) was collected. Screening test was accomplished using commercial chromogenic medium (ChromID ESBL agar; bioM茅rieux, Marcy l'Etoile, France). The presence of ESBLs of grown isolates was confirmed by Clinical and Laboratory Standards Institute guidelines. Analysis of the risk factors of ESBL-E carriage was performed by multivariate logistic regression.
Results
Among the risk factors, multivariate analysis demonstrated that prolonged hospitalization (鈮?0聽days) (odds ratio [OR], 6.76; 95% confidence interval [CI]: 1.17-39.23; P聽=聽.033), prolonged intensive care unit stay (鈮?4 days) (OR, 4.78; 95% CI: 1.70-13.42; P聽=聽.003), and methicillin-resistant Staphylococcus aureus carriage (OR, 3.29; 95% CI: 1.20-9.01; P聽=聽.020) were found to be significantly associated with fecal carriers.
Conclusion
This study clarified the characteristics and the risk factors of hospitalized patients carrying ESBL-E. In addition, the cost-benefit of routine screening in addition to methicillin-resistant Staphylococcus aureus and vancomycin-resitant Enterococci needs to be assessed.