Inactivation of the FoxO3a transcription factor is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated senescence in human colon cancer and breast cancer cells
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- 作者：Seong-Yeol Park ; Young-Seuk Bae ; ysbae@knu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：FoxO3a ; Senescence ; Reactive oxygen species ; Protein kinase CK2 ; Antioxidant
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：18-24
- 全文大小：1528 K
文摘
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FoxO3a overexpression inhibited ROS production mediated by CK2α knockdown.
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CK2α downregulation induced nuclear export of FoxO3a via AKT activation.
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CK2α downregulation reduced transcription of FoxO3a target genes including SOD.
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CK2α upregulation elevated nuclear import and target gene expression of FoxO3a.
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This study indicates that CK2 can modulate the intracellular ROS level via FoxO3a.