Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate

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• 作者：Yi Kou ; Myong Chul Koag ; Young Cheun ; Aram Shin ; Seongmin Lee
• 关键词：Hypoiodite ; Solasodine acetate ; Aminyl radical cyclization ; Steroidal alkaloid ; Oxazaspiroketal
• 刊名：Steroids
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：77
• 期：11
• 页码：1069-1074
• 全文大小：782 K

文摘

Solasodine acetate, an anticancer steroidal alkaloid, was synthesized from diosgenin in 8 steps with an overall yield of 23 % . A key synthetic step involves the formation of 5/6-oxazaspiroketal moiety via hypoiodite-mediated aminyl radical cyclization of a steroidal primary amine.