High prevalence of non-clonal imipenem-nonsusceptible Enterobacter spp. isolates in Korea and their association with porin down-regulation

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• 作者：Ji-Young Lee ; Yoon-Kyoung Hong ; Haejeong Lee ; Kwan Soo Ko ; ^{ksko@skku.edu}
• 关键词：Enterobacter cloacae ; Enterobacter aerogenes ; Imipenem ; Porin
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：1
• 页码：53-59
• 全文大小：947 K
• 卷排序：87

文摘

Prevalence, clonal distribution, and resistance mechanisms of imipenem-nonsusceptible Enterobacter clinical isolates from hospitals in Korea were investigated. Among 357 Enterobacter isolates from eight geographically distant tertiary care hospitals in Korea, a total of 31 isolates (8.7%) were not susceptible to imipenem. Judging from MLST and ERIC-PCR, imipenem resistance seems to have occurred independently in both Enterobacter species, E. cloacae and E. aerogenes. Decreased porin expression was found to be the main mechanism underlying this reduced susceptibility to imipenem.