Lesions Simulating Retinoblastoma (Pseudoretinoblastoma) in 604 Cases: Results Based on Age at Presentation

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• 作者：Carol L. Shields ; MD ; ^{carol.shields@shieldsoncology.com} ; Elizabeth Schoenberg ; BS ; Kristen Kocher ; BS ; Shripaad Y. Shukla ; MD ; Swathi Kaliki ; MD ; Jerry A. Shields ; MD
• 刊名：Ophthalmology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：120
• 期：2
• 页码：311-316
• 全文大小：1403 K

文摘

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Purpose

To determine the types and frequency of ocular conditions that simulate retinoblastoma (pseudoretinoblastoma) based on age at presentation.

Design

Retrospective case series.

Participants

Two thousand seven hundred seventy-five patients.

Methods

Chart review.

Main Outcome Measures

Conditions simulating retinoblastoma.

Results

Of 2775 patients referred for management of retinoblastoma, 2171 patients (78 % ) had confirmed retinoblastoma and 604 patients (22 % ) had simulating lesions (pseudoretinoblastomas). In the pseudoretinoblastoma cohort, the mean patient age at presentation was 4 years (median, 2 years). There were 27 different pseudoretinoblastoma conditions, and the 10 most common included Coats' disease (n = 244; 40 % ), persistent fetal vasculature (PFV; n = 158; 28 % ), vitreous hemorrhage (n = 27; 5 % ), ocular toxocariasis (n = 22; 4 % ), familial exudative vitreoretinopathy (FEVR; n = 18; 3 % ), rhegmatogenous retinal detachment (n = 18; 3 % ), coloboma (n = 17; 3 % ), astrocytic hamartoma (n = 15; 2 % ), combined hamartoma of retina and retinal pigment epithelium (n = 15; 2 % ), and endogenous endophthalmitis (n = 10; 2 % ). Simulating lesions differed based on age at presentation, and children younger than 1 year were most likely to have PFV (49 % ), Coats' disease (20 % ), or vitreous hemorrhage (7 % ); those 2 to 5 years of age were most likely to have Coats' disease (61 % ), toxocariasis (8 % ), or PFV (7 % ); and those older than 5 years were most likely to have Coats' disease (57 % ), toxocariasis (8 % ), or FEVR (6 % ).

Conclusions

The most common pseudoretinoblastomas include Coats' disease, PFV, and vitreous hemorrhage, but the spectrum varies depending on patient age.

Financial Disclosure(s)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.