Visceral hyperalgesia in children with functional abdominal pain

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• 作者：Carlo Di Lorenzo ; Nader N. Youssef ; Luther Sigurdsson ; Lisa Scharff ; Janet Griffiths ; Arnold Wald
• 刊名：The Journal of Pediatrics
• 出版年：2001
• 出版时间：December 2001
• 年：2001
• 卷：139
• 期：6
• 页码：838-843
• 全文大小：95 K

文摘

Objective: Our purpose was to evaluate visceral sensitivity and psychologic profiles in children with functional gastrointestinal disorders. Study design: We measured visceral perception in the stomach and in the rectum by using an electronic barostat. Psychologic questionnaires were completed. Ten children with recurrent abdominal pain (RAP)(8 female, mean age 11.3 ± 0.8 years), 10 children with irritable bowel syndrome (IBS) (8 female, mean age 13.0 ± 0.9 years), and 15 control children (8 female, mean age 12.7 ± 1.2 years) completed the study. Results: Thresholds for visceral perception in the rectum were decreased in patients with IBS (P < .001 vs control patients) and in patients with RAP (P < .05 vs control patients). Children with IBS had lower thresholds than children with RAP (P < .01). In contrast, thresholds for perception were decreased in the stomach of children with RAP (P < .005 vs control patients) but not in children with IBS. There were elevated anxiety scores in 45 % of patients. Duration of symptoms was associated with higher scores of anxiety (P < .001) and depression (P < .02). Conclusions: Hyperalgesia was demonstrated in children with RAP and IBS; sites of hyperalgesia appear to be associated with different symptom phenotypes; anxiety was common, and there was an association between the duration of symptoms and increased scores for both anxiety and depression. (J Pediatr 2001;139:838–43)