The prevalence of anxiety and depression in patients with or without hyperhidrosis (HH)

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• 作者：Rayeheh Bahar ; MD^a ; Pingyu Zhou ; MD ; PhD^b ; Yudan Liu ; MD ; MS^b ; Yuanshen Huang ; MD ; PhD^a ; Arlie Phillips ; RN^a ; Tim K. Lee ; PhD^a ; Mingwan Su ; PhD^a ; Sen Yang ; MD ; PhD^c ; Sunil Kalia ; MD ; MS^a ; Xuejun Zhang ; MD ; PhD^c ; Youwen Zhou ; MD ; PhD^a ; ^{youwen.zhou@ubc.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：anxiety ; depression ; dermatology ; late-onset hyperhidrosis ; multivariable logistic regression analysis ; negative impact ; primary hyperhidrosis
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：75
• 期：6
• 页码：1126-1133
• 全文大小：553 K

文摘

There are conflicting data about the correlation between hyperhidrosis (HH) and anxiety and depression.

Objective

We sought to determine the prevalence of anxiety and depression in patients with or without HH.

Methods

We examined 2017 consecutive dermatology outpatients from Vancouver, British Columbia, Canada, and Shanghai, China, using Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scales for anxiety and depression assessments. Multivariable logistic regression analysis was performed to evaluate if the impact of HH on anxiety and depression is dependent on demographic factors and diagnoses of the patients' presenting skin conditions.

Results

The prevalence of anxiety and depression was 21.3% and 27.2% in patients with HH, respectively, and 7.5% and 9.7% in patients without HH, respectively (P value <.001 for both). There were positive correlations between HH severity and the prevalence of anxiety and depression. Multivariable analysis showed that HH-associated increase in anxiety and depression prevalence is independent of demographic factors and presenting skin conditions.

Limitation

The data from the questionnaires relied on the accuracy of patients' self-reports.

Conclusion

Both single variant and multivariable analyses showed a significant association between HH and the prevalence of anxiety and depression in a HH severity–dependent manner.