Immune suppressive properties of artemisinin family drugs

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• 作者：Lifei Hou¹ ; Haochu Huang ; ^{hhuang@bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CD ; cluster of differentiation ; CIA ; collagen-induced arthritis ; EAE ; experimental allergic encephalomyelitis ; IL ; interleukin ; TCR ; T cell receptor ; Th ; T helper ; Treg ; regulatory T cell
• 刊名：Pharmacology and Therapeutics
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：166
• 期：Complete
• 页码：123-127
• 全文大小：1070 K

文摘

Artemisinin and its derivatives are the first-line antimalarial drugs, and have saved millions of lives across the globe, especially in developing world. The discovery of artemisinin by Youyou Tu was awarded the 2015 Nobel Prize in Physiology or Medicine. In addition to treating malaria, accumulating evidences suggest that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. We recently showed that artesunate, an artemisinin analog, dramatically ameliorated autoimmune arthritis by selectively diminishing germinal center B cells. Herein, we review the immunosuppressive properties of artemisinin family drugs and the potential underlying mechanisms.