Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010

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• 作者：Cheng-Mao Ho^a ; Mao-Wang Ho^a ; Yung-Ching Liu^b ; Han-Siong Toh^c ; Yu-Lin Lee^d ; Yuag-Meng Liu^e ; Chi-Chang Huang^f ; Po-Liang Lu^g ; Chun-Eng Liu^h ; Yen-Hsu Chenⁱ ; Wen-Chien Ko^f ; ^j ; Hung-Jen Tang^k ; Kwok-Woon Yu^l ; Yao-Shen Chen^m ; Yin-Ching Chuangⁿ ; Jen-Hsien Wang^o ; ^{wangjenhsien@gmail.com} ; Po-Ren Hsueh^p ; ^{hsporen@ntu.edu.tw}
• 关键词：Enterobacteriaceae ; Intra-abdominal infections ; Carbapenem resistance ; Carbapenem consumption ; SMART
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：40
• 期：supp_S1
• 页码：S24-S28
• 全文大小：1K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences<h3 class=""h3"">Summaryh3>We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of nonsusceptibility ranged from 3.5 % to 10.3 % and those for imipenem ranged from 3.5 % to 10.7 % . Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented.