Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells
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- 作者：Daoyuan Ren ; Ning Wang ; Jianjun Guo ; Li Yuan ; yuanli112086@snnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xingbin Yang ; xbyang@snnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pleurotus eryngii ; Polysaccharide ; Purification ; Anti-proliferation ; Cell cycle ; Apoptosis
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：123-133
- 全文大小：2061 K
文摘
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PEP is the crude heteropolysaccharides isolated from Pleurotus eryngii.
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PEP-1 and PEP-2 were purified from PEP by Cellulose DEAE-52 and Sephadex G-100.
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High molecular mass PEP-2 exhibits more potent anticancer effect than PEP-1.
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ROS was a critical mediator in PEP-2 induced HepG-2 cellular apoptosis.
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PEP-2 is a good candidate for dietary supplement and therapeutic application in cancer.