Pathogenic conversion of regulatory B10 cells into osteoclast-priming cells in rheumatoid arthritis

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• 作者：Fanlei Hu^a ; ¹ ; Hongjiang Liu^b ; ¹ ; Xu Liu^a ; Xia Zhang^a ; Liling Xu^a ; Huaqun Zhu^a ; Yingni Li^a ; Lianjie Shi^c ; Limin Ren^a ; Jian Zhang^a ; Zhanguo Li^a ; ^{li99@bjmu.edu.cn} ; Yuan Jia^a ; ^{jiayuan1023@sina.com}
• 关键词：Rheumatoid arthritis ; Regulatory B10 cells ; Osteoclasts ; RANKL
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：53-62
• 全文大小：3143 K
• 卷排序：76

文摘

Regulatory B10 cells were functionally impaired in RA patients . Under RA circumstance, regulatory B10 cells demonstrated the potential of converting into RANKL-producing cells . RANKL-producing B10 cells expanded dramatically in RA patients and were positively correlated with the disease activities . RANKL-producing B10 cells from RA patients significantly promoted osteoclast differentiation and bone erosion . RANKL-producing B10 cells declined while regulatory B10 cells increased in RA patients with remission after therapy .