Development and validation of an LC-MS/MS method for the determination of SB-505124 in rat plasma: Application to pharmacokinetic study
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- 作者：Jiayu Jianga ; Yuandong Zhanga ; Quan Zhanga ; Yanping Lia ; Tao Gonga ; Zhirong Zhanga ; Rui Dingb ; dingrui1001@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Xun Suna ; sxcelia22@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SB-505124 ; LC&ndash ; MS/MS ; Validation ; Pharmacokinetic study ; Rat plasma
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：205-209
- 全文大小：766 K
文摘
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The first report for the quantification of SB-505124 applied to in vivo studies.
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The established method was simple, good sensitivity and rapid analysis time.
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The method has been validated following bioanalytical validation guidelines and successfully applied to a pharmacokinetic study of SB-505124 in rats.
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The pharmacokinetic parameters of SB-505124 in this paper are reported for the first time.