The influence of influenza A (H1N1) virus on creatinine and cystatin C

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• 作者：Zhidong Guo ; Qiqi Wang ; Zhangying Wu ; Jianhua Zhu ; Yuangang Qiu ; Liangrong Zheng ; Lifeng Qiu
• 关键词：Influenza A (H1N1) ; Kidney injury ; Creatinine (Cr) ; Cystatin C (Cy-C)
• 刊名：Clinica Chimica Acta
• 出版年：2010
• 出版时间：14 December 2010
• 年：2010
• 卷：411
• 期：23-24
• 页码：2040-2042
• 全文大小：295 K

文摘

Background

In March 2009, the novel 2009 influenza A (H1N1) virus was first reported in the southwestern USA and Mexico. It rapidly spread to China and worldwide. We investigated possible kidney injury in patients with the 2009 influenza A (H1N1) virus in China.

Methods

This study was a retrospective cohort investigation of the potential renal injury in patients of influenza. One hundred and seventy-two patients confirmed to have the 2009 influenza A (H1N1) virus but who had different levels of severity (non-severe, severe, and critically severe) and 21 cases who were influenza A (H1N1)-negative but who had an influenza-like illness were investigated. Blood samples were obtained for the measurement of creatinine (Cr) and cystatin C (Cy-C).

Results

The influenza A (H1N1) virus caused more illness in middle-aged people in all groups. The patients in the non-severe group were younger than those in the severe group (p < 0.05) and the non-influenza A (H1N1) group (p < 0.01). Four subjects in the critically severe group died (3 due to respiratory failure, 1 heart injury). A significant difference in the levels of Cr and Cy-C between the groups was not observed (p > 0.05).

Conclusion

The 2009 influenza A (H1N1) virus did not cause severe kidney injury in the acute phase in adult patients.