A bifunctional Fe (III)-coordinated nanoprobe for electrochemical detection of sphingosine kinase 1 activity
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- 作者：Shiyu Gua ; 1 ; Tao Gaoa ; 1 ; Yucai Yangb ; Jun Zhia ; Jinlong Lia ; Yang Xianga ; xiangy@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Keming Wangb ; wangkeminglab@163.com" class="auth_mail" title="E-mail the corresponding author ; Jie Yanga ; yangjie@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bifunctional nanoprobe ; Coordinated Fe (III) ion ; Kinase ; Phosphorylation ; Lipid-simulating surface
- 刊名：Electrochemistry Communications
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：104-108
- 全文大小：775 K
文摘
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Simplified kinase analysis was demonstrated by utilizing an electrochemical assay composed of iron based nanoprobe.
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Dual signal amplification was achieved by the designed strategy to ensure high sensitivity.
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A lipid kinase was detected as a proof-of-concept in its catalytic environment at the electrode surface.