Gamma glutamyltransferase, inflammation and cardiovascular risk factors in isolated coronary artery ectasia

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• 作者：Abdullah Dogan ; Akif Arslan ; ^{dr.akifarslan@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Habil Yucel ; Fatih Aksoy ; Atilla Icli ; Mehmet Ozaydin ; Ercan Varol ; Dogan Erdogan
• 关键词：Coronary ectasia ; Risk factors ; Inflammation ; Gamma glutamyltransferase
• 刊名：Revista Portuguesa de Cardiologia
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：35
• 期：1
• 页码：33-39
• 全文大小：550 K

文摘

There are conflicting data on the prevalence of cardiovascular risk factors in coronary artery ectasia (CAE). It is unclear whether CAE is associated with high-sensitivity C-reactive protein (hs-CRP) and gamma glutamyltransferase (GGT). We therefore investigated major cardiovascular risk factors, serum GGT and hs-CRP levels in a large population of patients with CAE.

bsSec_2">Methods

A total of 167 patients with isolated CAE and 150 controls with normal coronary arteries were selected from 10 505 patients undergoing coronary angiography. Serum GGT and hs-CRP levels were evaluated in addition to cardiovascular risk factors including family history, obesity, smoking, diabetes, hypertension and hyperlipidemia.

bsSec_3">Results

Hypertension and obesity were slightly more prevalent in CAE patients than in controls, whereas diabetes was slightly less frequent in CAE patients. Other risk factors were similar. Serum GGT (22 [17–42] vs. 16 [13–21] U/l, p=0.001) and hs-CRP (2.9 [1.9–3.6] vs. 1.4 [1.1–1.8] mg/l, p=0.001) levels were higher in CAE patients than in controls. The presence of CAE was independently associated with diabetes (OR: 0.44, 95% CI: 0.20–0.95, p=0.04), obesity (OR: 2.84, 95% CI: 1.07–7.56, p=0.04), GGT (OR: 1.08, 95% CI: 1.03–1.12, p=0.001) and hs-CRP levels (OR: 3.1, 95% CI: 2.1–4.6, p=0.001). In addition, GGT and hs-CRP levels were higher in diffuse and multivessel ectasia subgroups than focal and single-vessel ectasia subgroups (each p<0.05).

bsSec_4">Conclusions

Our findings show that CAE can be independently and positively associated with obesity, GGT and hs-CRP levels, but inversely with diabetes. Moreover, its severity may be related to GGT and hs-CRP levels.